Sandbox Reserved 1101: Difference between revisions

Line 2:

'~~''5IZ2 :~~ ''N~~. Clavipes'' spidroin NTD~~'''

'''N-terminal domain of Major-ampullate Spidroin protein'''

----

5IZ2 is the ~~'''~~NTD ~~domain'''~~ of a protein called ~~[https://en.wikipedia.org/wiki/Spidroin_ spidroin]~~. This protein is a component of ~~the '~~''dragline silk'''~~. There are several types of spidroin, and those that form the core of the silk are called '''MaSp1''' (Major ampullate Spidroin-1), which are~~ produced by in the major ampullate gland of spiders<ref name="Atkison"/>.

5IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of ''dragline silk''' produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.

The NTD domain of ~~these proteins is very important since it~~ plays a major role in ~~the '''dimerization of spidroins'''~~<ref name="Atkison"/>. Indeed, thanks to the NTD ~~organization~~, two ~~spidroins~~ can be ~~combined~~, leading to the ~~production~~ of fibres with exceptional physical qualities<ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>.

The study of the N. Clavipes NTD permits to compare its structure with other species thus to provide new insights into the mechanism of NTD dimerization. Moreover, silks produced from different spider breeds vary in physical properties such as toughness and elasticity. In this way, studying diverse species would allow to optimize artificial silk for different applications.

==Generalities on fiber assembly of dragline silks==

Sandbox Reserved 1101: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 2: / Line 2: @@
-'''5IZ2 : ''N. Clavipes'' spidroin NTD'''
+'''N-terminal domain of Major-ampullate Spidroin protein'''
 ----
-IZ2 is the '''NTD domain''' of a protein called [https://en.wikipedia.org/wiki/Spidroin_ spidroin]. This protein is a component of the '''dragline silk'''. There are several types of spidroin, and those that form the core of the silk are called '''MaSp1''' (Major ampullate Spidroin-1), which are produced by in the major ampullate gland of spiders<ref name="Atkison"/>.
+IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of ''dragline silk''' produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.
-The NTD domain of these proteins is very important since it plays a major role in the '''dimerization of spidroins'''<ref name="Atkison"/>. Indeed, thanks to the NTD organization, two spidroins can be combined, leading to the production of fibres with exceptional physical qualities<ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>.
+The study of the N. Clavipes NTD permits to compare its structure with other species thus to provide new insights into the mechanism of NTD dimerization. Moreover, silks produced from different spider breeds vary in physical properties such as toughness and elasticity. In this way, studying diverse species would allow to optimize artificial silk for different applications.
 ==Generalities on fiber assembly of dragline silks==