Sandbox Reserved 1101: Difference between revisions

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5IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of ''dragline silk~~'''~~ produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.

5IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of dragline silk produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.

The study of the N. Clavipes NTD permits to compare its structure with other species thus to provide new insights into the mechanism of NTD dimerization. Moreover, silks produced from different spider breeds vary in physical properties such as toughness and elasticity. In this way, studying diverse species would allow to optimize artificial silk for different applications.

Sandbox Reserved 1101: Difference between revisions

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-IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of ''dragline silk''' produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.
+IZ2 is the N-terminal domain (NTD) of a spider protein called Major ampullate Spidroin 1A (MaSp1A), coming from the Nephila Clavipes species. This protein is a component of dragline silk produced in the major ampullate gland of spiders <ref name="Atkison"/>. The NTD domain of MaSp1A plays a major role in their combination during silk production <ref name="Atkison"/>. Indeed, thanks to the NTD dimerisation, two MaSps can be connected, leading to the formation of fibres with exceptional physical and biochemical qualities <ref name="José">José Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Helga Priewalder, Heliana Clara Salles, Mario Sergio Palma and Gert Lubec, 2015. Structural Model for the Spider Silk Protein Spidroin‑1, Journal of Proteome research, 14, p.3859-3870.</ref>. It is of biotechnological interest to deeply understand the NTD dimerisation mechanism for the production of artificial spider silk, which can lead to innovative biomaterials.
 The study of the N. Clavipes NTD permits to compare its structure with other species thus to provide new insights into the mechanism of NTD dimerization. Moreover, silks produced from different spider breeds vary in physical properties such as toughness and elasticity. In this way, studying diverse species would allow to optimize artificial silk for different applications.