Sandbox Reserved 1100: Difference between revisions

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AdipoR1 is involved in different diseases and symptoms. One major diseases linked with this proteine is the [http://en.wikipedia.org/wiki/Type_2_diabetes Type II diabete] which is caracterized by a chronic hyperglycemia. This disease is mainly present in obese or overweight people. In case of type II diabete, adiponectin level in plasma is reduced signficantly and the expression of the adiponectin receptors,AdipoR1, decreases, especially in [http://en.wikipedia.org/wiki/Skeletal_muscle skeletal muscle] and [http://en.wikipedia.org/wiki/Adipose_tissue adipose tissues] .<ref name="doc3"/> <ref name="doc7"/>

Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects of a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>.

Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects of a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>. Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.

Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.

Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor (AdipoR1) should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which improves insulin resistance and promotes glucose uptake in skeletal muscle in one hand, and attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages in the other hand<ref name="doc5"/>.

Sandbox Reserved 1100: Difference between revisions

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 AdipoR1 is involved in different diseases and symptoms. One major diseases linked with this proteine is the [http://en.wikipedia.org/wiki/Type_2_diabetes Type II diabete] which is caracterized by a chronic hyperglycemia. This disease is mainly present in obese or overweight people. In case of type II diabete, adiponectin level in plasma is reduced signficantly and the expression of the adiponectin receptors,AdipoR1, decreases, especially in [http://en.wikipedia.org/wiki/Skeletal_muscle skeletal muscle] and [http://en.wikipedia.org/wiki/Adipose_tissue adipose tissues] .<ref name="doc3"/> <ref name="doc7"/>
-Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects of a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>.
+Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects of a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>. Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.
-Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.
 Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor (AdipoR1) should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which improves insulin resistance and promotes glucose uptake in skeletal muscle in one hand, and attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages in the other hand<ref name="doc5"/>.