Sandbox Reserved 1100: Difference between revisions

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Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects compare to a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>. Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.

Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor ~~(AdipoR1)~~ should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which in the one hand improves insulin resistance and promotes glucose uptake in skeletal muscle,and in the other hand attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages<ref name="doc5"/>.

Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor 1 should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which in the one hand improves insulin resistance and promotes glucose uptake in skeletal muscle,and in the other hand attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages<ref name="doc5"/>.

Sandbox Reserved 1100: Difference between revisions

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Revision as of 22:28, 16 January 2020 view source Judith Weber (talk \| contribs) 84 edits No edit summary ← Older edit		Revision as of 22:29, 16 January 2020 view source Emilie Felice (talk \| contribs) 79 edits No edit summary Newer edit →
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	Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects compare to a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>. Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.		Another symptom linked to adipoR1 is the insulin resistance. An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism is an organism which will require more insulin to obtain the biological effects compare to a normal organism<ref name="doc8"/>.Insulin resistance can be caused by any defects in the insulin signaling cascade, including problems with AdipoR1<ref name="doc8"/>.[http://en.wikipedia.org/wiki/Hyperglycemia Hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] are probably the cause of insulin resistance<ref name="doc3"/>. In fact, The adiponectin levels and the expression of AdipoR1 drop, reducing adiponectin sensitivity and so lead to insulin resistance<ref name="doc8"/>. Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increasing hyperinsulinemia.This is the start of a vicious cycle<ref name="doc7"/> <ref name="doc3"/>.

	Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor ~~(AdipoR1)~~ should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which in the one hand improves insulin resistance and promotes glucose uptake in skeletal muscle,and in the other hand attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages<ref name="doc5"/>.		Obesity and insulin resistance also lead to [http://en.wikipedia.org/wiki/Metabolic_syndrome metabolic syndrome].Indeed,adipoR1 can display metabolic dysfunction, especially in case of the drop of its expression<ref name="doc5"/>.However agonist of adiponectin receptor 1 should be a new treatment strategie for metabolic syndrome or obesity-linked diseases<ref name="doc3"/>.Moreover,a treatment against type II diabete and insulin resistance could be AdipoR1 overexpression, which in the one hand improves insulin resistance and promotes glucose uptake in skeletal muscle,and in the other hand attenuates weight gain and improves glucose metabolism models of metabolic dysfunction in macrophages<ref name="doc5"/>.