Sandbox Reserved 1097: Difference between revisions
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=== The active site === | === The active site === | ||
* '''Structure''' | * '''Structure''' | ||
The active site is located in the tyrosinase-like subdomain. It is delimited by four helices and contains the binuclear metal-binding site. It looks like type-3 binuclear [https://en.wikipedia.org/wiki/Copper_protein copper-binding site] of Tyrosinases. Both ions are bound with planar trigonal geometry and the distance between them is : 3,5 ± 0,1 Ā. A molecule of water located at the same distance (2,1 ± 0,1 Ā) from the two ions can make a bridge between them. Mutations on amino acids of the active site do not significantly affect TYRP1 activity.<ref name= "lai"/> | <scene name='82/829350/Active_site/2'>The active site</scene> is located in the tyrosinase-like subdomain. It is delimited by four helices and contains the binuclear metal-binding site. It looks like type-3 binuclear [https://en.wikipedia.org/wiki/Copper_protein copper-binding site] of Tyrosinases. Both ions are bound with planar trigonal geometry and the distance between them is : 3,5 ± 0,1 Ā. A molecule of water located at the same distance (2,1 ± 0,1 Ā) from the two ions can make a bridge between them. Mutations on amino acids of the active site do not significantly affect TYRP1 activity.<ref name= "lai"/> | ||
* '''Ligand interactions''' | * '''Ligand interactions''' | ||
