Sandbox Reserved 1103: Difference between revisions

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[https://en.wikipedia.org/wiki/TERF1 TRF1]TRF1 also called [https://en.wikipedia.org/wiki/TERF1 TERF1] is a protein part of the [https://en.wikipedia.org/wiki/Shelterin Shelterin] complex (also called telosome) that has a crucial role in the regulation of telomeres <ref>PMID: 31261825</ref>. TRF1 is an inhibitor of [[Telomerase]], the protein that elongates telomeres. Indeed, when TRF1 is inactivated, telomeres are getting longer with no regulation.

The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerize to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or [https://en.wikipedia.org/wiki/TERF2 TRF2] that are others proteins of the shelterin complex. This link will regulate their activity and can also stabilize TRF1’s interaction with DNA.

The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerize to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref name="doc1"> PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or [https://en.wikipedia.org/wiki/TERF2 TRF2] that are others proteins of the shelterin complex. This link will regulate their activity and can also stabilize TRF1’s interaction with DNA.

When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]].

Because of their function in telomeres regulation, TRF1 TIN2 are key proteins involved in cell aging and their dysfunction can directly leads to disease like cancer or other cell cycle diseases.

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 [https://en.wikipedia.org/wiki/TERF1 TRF1]TRF1 also called [https://en.wikipedia.org/wiki/TERF1 TERF1] is a protein part of the  [https://en.wikipedia.org/wiki/Shelterin Shelterin] complex (also called telosome) that has a crucial role in the regulation of telomeres <ref>PMID: 31261825</ref>. TRF1 is an inhibitor of [[Telomerase]], the protein that elongates telomeres. Indeed, when TRF1 is inactivated, telomeres are getting longer with no regulation.
-The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerize to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or [https://en.wikipedia.org/wiki/TERF2 TRF2] that are others proteins of the shelterin complex. This link will regulate their activity and can also stabilize TRF1’s interaction with DNA.
+The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerize to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref name="doc1"> PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or [https://en.wikipedia.org/wiki/TERF2 TRF2] that are others proteins of the shelterin complex. This link will regulate their activity and can also stabilize TRF1’s interaction with DNA.
 When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]].
 Because of their function in telomeres regulation, TRF1 TIN2 are key proteins involved in cell aging and their dysfunction can directly leads to disease like cancer or other cell cycle diseases.