Sandbox Reserved 1097: Difference between revisions
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== Comparison between enzymes of the Tyrosinase family == | == Comparison between enzymes of the Tyrosinase family == | ||
In mammals, three enzymes of Tyrosinase family may be involved in the biosynthesis of melanin. [[Tyrosinase]] (TYR) reacts two times in the mechanism whereas Tyrosinase Related Protein 1 and 2 (TYRP1 and TYRP2) probably catalyze only one reaction in this biosynthesis. TYR is an oxydoreductase,TYRP2 seems to act as a tautomerase and the exact role in melanin synthesis of human TYRP1 is still under debate. In fact in mice, TYRP1 can especially catalyze the reaction of DHICA in eumelanin but human TYR can also do the same.<ref name = "decker"/> No human cristal structure is available for TYR, so thanks to cristal structure of TYRP1, it is possible to deduce a good model of TYR. | [[Image:Melanin biosynthesis.jpg|thumb|right|upright=1.5|Melanin biosynthesis information extracted from https://reactome.org/PathwayBrowser/#/R-HSA-5662702]] In mammals, three enzymes of Tyrosinase family may be involved in the biosynthesis of melanin. [[Tyrosinase]] (TYR) reacts two times in the mechanism whereas Tyrosinase Related Protein 1 and 2 (TYRP1 and TYRP2) probably catalyze only one reaction in this biosynthesis. TYR is an oxydoreductase,TYRP2 seems to act as a tautomerase and the exact role in melanin synthesis of human TYRP1 is still under debate. In fact in mice, TYRP1 can especially catalyze the reaction of DHICA in eumelanin but human TYR can also do the same.<ref name = "decker"/> No human cristal structure is available for TYR, so thanks to cristal structure of TYRP1, it is possible to deduce a good model of TYR. | ||
==== Similarities ==== | ==== Similarities ==== | ||
