Sandbox Reserved 1107: Difference between revisions
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Drug resistant bacteria are the cause of death of millions of people worldwide. In the USA alone, hospital infections associated with antibiotic-resistant pathogens cause 99 000 deaths per year<ref name="more2">PMID:30349322</ref>. The development of new antibiotics with new mechanism of action is urgent. This crystal structure, 6OYH, serve as a generalizable MraY structural model to study and better understand the action of the nucleosides inhibitors. Moreover, the sttructural analysis of the binding of carbacaprazamycin to MraYAA provides a better understanding of the chemical logic of MraY inhibition, which can help in the development of novel approaches for the design of antibiotics targeting MraY. | Drug resistant bacteria are the cause of death of millions of people worldwide. In the USA alone, hospital infections associated with antibiotic-resistant pathogens cause 99 000 deaths per year<ref name="more2">PMID:30349322</ref>. The development of new antibiotics with new mechanism of action is urgent. This crystal structure, 6OYH, serve as a generalizable MraY structural model to study and better understand the action of the nucleosides inhibitors. Moreover, the sttructural analysis of the binding of carbacaprazamycin to MraYAA provides a better understanding of the chemical logic of MraY inhibition, which can help in the development of novel approaches for the design of antibiotics targeting MraY. | ||
= 3D related structures = | = 3D related structures = | ||
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*[[5jnq]]:MraY tunicamycin complex | *[[5jnq]]:MraY tunicamycin complex | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
