6tm1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6tm1 is ~~ON HOLD~~

==Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3==

~~Authors~~: ~~Barford~~, D., ~~Fan~~, D., ~~Cronin~~, N.~~, Yang, J~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6tm1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TM1 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of the ~~DHR2 domain~~ of ~~DOCK10 in complex with RAC3~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tm1 OCA], [http://pdbe.org/6tm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tm1 RCSB], [http://www.ebi.ac.uk/pdbsum/6tm1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tm1 ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Barford, D]]

[[Category: Cronin, N]]

[[Category: Fan, D]]

[[Category: Yang, J]]

[[Category: ~~Fan, D~~]]

[[Category: Dock10 gef rac3 gtpase]]

[[Category: ~~Cronin, N~~]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6tm1 is ON HOLD
+==Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3==
+<StructureSection load='6tm1' size='340' side='right'caption='[[6tm1]], [[Resolution|resolution]] 3.71&Aring;' scene=''>
-Authors: Barford, D., Fan, D., Cronin, N., Yang, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6tm1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TM1 FirstGlance]. <br>
-Description: Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tm1 OCA], [http://pdbe.org/6tm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tm1 RCSB], [http://www.ebi.ac.uk/pdbsum/6tm1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tm1 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Barford, D]]
+[[Category: Cronin, N]]
+[[Category: Fan, D]]
 [[Category: Yang, J]]
-[[Category: Fan, D]]
+[[Category: Dock10 gef rac3 gtpase]]
-[[Category: Cronin, N]]
+[[Category: Signaling protein]]