6h10: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6h10 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6h10]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H10 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FJ8:~{N}-[(~{E})-(4-methylphenyl)methylideneamino]-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanamide'>FJ8</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h10 OCA], [http://pdbe.org/6h10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h10 RCSB], [http://www.ebi.ac.uk/pdbsum/6h10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h10 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Heinemann, U]]

[[Category: Link, A]]

[[Category: Malecki, P H]]

[[Category: Weiss, M S]]

[[Category: Cancer]]

[[Category: Epigenetic]]

[[Category: Inhibitor design]]

[[Category: Kdm4]]

[[Category: Ligand binding]]

[[Category: Oxidoreductase]]

[[Category: Tetrazole]]

[[Category: Tetrazolylhydrazide]]

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-'''Unreleased structure'''
-The entry 6h10 is ON HOLD  until Paper Publication
+==Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR073==
+<StructureSection load='6h10' size='340' side='right'caption='[[6h10]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h10]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H10 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FJ8:~{N}-[(~{E})-(4-methylphenyl)methylideneamino]-2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanamide'>FJ8</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h10 OCA], [http://pdbe.org/6h10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h10 RCSB], [http://www.ebi.ac.uk/pdbsum/6h10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h10 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Heinemann, U]]
+[[Category: Link, A]]
+[[Category: Malecki, P H]]
+[[Category: Weiss, M S]]
+[[Category: Cancer]]
+[[Category: Epigenetic]]
+[[Category: Inhibitor design]]
+[[Category: Kdm4]]
+[[Category: Ligand binding]]
+[[Category: Oxidoreductase]]
+[[Category: Tetrazole]]
+[[Category: Tetrazolylhydrazide]]