6sdf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6sdf ~~is ON HOLD until Paper Publication~~

==N-terminal SH3 domain of Grb2 protein==

~~Authors~~: ~~Bolgov, A~~.A.~~, Korban, S~~.A.~~, Luzik, D~~.A., ~~Rogacheva~~, O.N.~~, Zhemkov, V~~.A., ~~Kim, M~~.~~, Skrynnikov, N~~.R., ~~Bezprozvanny~~, I.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SDF FirstGlance]. <br>

~~Description: N-terminal SH3 domain of Grb2 protein~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>

[~~[Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdf OCA], [http://pdbe.org/6sdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sdf RCSB], [http://www.ebi.ac.uk/pdbsum/6sdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdf ProSAT]</span></td></tr>

[~~[Category~~: ~~Zhemkov, V~~.A]]

</table>

[[~~Category~~: ~~Luzik, D~~.A]]

== Function ==

~~[[Category~~: ~~Korban~~, S.~~A]]~~

[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>

[[Category: ~~Rogacheva, O.N~~]]

== References ==

[[Category: ~~Skrynnikov~~, ~~N.R~~]]

[[Category: ~~Bezprozvanny~~, ~~I.B~~]]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Bezprozvanny, I B]]

[[Category: Bolgov, A A]]

[[Category: Kim, M]]

[[Category: ~~Bolgov~~, A.A]]

[[Category: Korban, S A]]

[[Category: Luzik, D A]]

[[Category: Rogacheva, O N]]

[[Category: Skrynnikov, N R]]

[[Category: Zhemkov, V A]]

[[Category: Grb2]]

[[Category: Growth factor]]

[[Category: Sh3-domain]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6sdf is ON HOLD  until Paper Publication
+==N-terminal SH3 domain of Grb2 protein==
+<StructureSection load='6sdf' size='340' side='right'caption='[[6sdf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Bolgov, A.A., Korban, S.A., Luzik, D.A., Rogacheva, O.N., Zhemkov, V.A., Kim, M., Skrynnikov, N.R., Bezprozvanny, I.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SDF FirstGlance]. <br>
-Description: N-terminal SH3 domain of Grb2 protein
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdf OCA], [http://pdbe.org/6sdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sdf RCSB], [http://www.ebi.ac.uk/pdbsum/6sdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdf ProSAT]</span></td></tr>
-[[Category: Zhemkov, V.A]]
+</table>
-[[Category: Luzik, D.A]]
+== Function ==
-[[Category: Korban, S.A]]
+[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>   Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
-[[Category: Rogacheva, O.N]]
+== References ==
-[[Category: Skrynnikov, N.R]]
+<references/>
-[[Category: Bezprozvanny, I.B]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Bezprozvanny, I B]]
+[[Category: Bolgov, A A]]
 [[Category: Kim, M]]
-[[Category: Bolgov, A.A]]
+[[Category: Korban, S A]]
+[[Category: Luzik, D A]]
+[[Category: Rogacheva, O N]]
+[[Category: Skrynnikov, N R]]
+[[Category: Zhemkov, V A]]
+[[Category: Grb2]]
+[[Category: Growth factor]]
+[[Category: Sh3-domain]]
+[[Category: Signaling protein]]