6uz6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6uz6 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of GLUN1/GLUN2A-4M mutant ligand-binding domain in complex with glycine and glutamate==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6uz6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UZ6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uz6 OCA], [http://pdbe.org/6uz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uz6 RCSB], [http://www.ebi.ac.uk/pdbsum/6uz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uz6 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Furukawa, H]]

[[Category: Wang, J X]]

[[Category: Agonist]]

[[Category: Ligand-binding domain]]

[[Category: Membrane protein]]

[[Category: Nmdar]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6uz6 is ON HOLD  until Paper Publication
+==Crystal structure of GLUN1/GLUN2A-4M mutant ligand-binding domain in complex with glycine and glutamate==
+<StructureSection load='6uz6' size='340' side='right'caption='[[6uz6]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6uz6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UZ6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uz6 OCA], [http://pdbe.org/6uz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uz6 RCSB], [http://www.ebi.ac.uk/pdbsum/6uz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uz6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>  [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Furukawa, H]]
+[[Category: Wang, J X]]
+[[Category: Agonist]]
+[[Category: Ligand-binding domain]]
+[[Category: Membrane protein]]
+[[Category: Nmdar]]