6vfy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6vfy is ~~ON HOLD~~

==Crystal structure of mouse acyl-CoA thioesterase 7 with CoA==

~~Authors~~: ~~Teakel~~, S.L., ~~Forwood~~, J.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[6vfy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VFY FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~mouse~~ acyl-CoA ~~thioesterase 7~~ with CoA

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </td></tr>

[[Category: Forwood, J.K]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vfy OCA], [http://pdbe.org/6vfy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vfy RCSB], [http://www.ebi.ac.uk/pdbsum/6vfy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vfy ProSAT]</td></tr>

[[Category: Teakel, S.L]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BACH_MOUSE BACH_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.<ref>PMID:11834298</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Palmitoyl-CoA hydrolase]]

[[Category: Forwood, J K]]

[[Category: Teakel, S L]]

[[Category: Coenzyme some]]

[[Category: Hydrolase]]

[[Category: Thioesterase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6vfy is ON HOLD
+==Crystal structure of mouse acyl-CoA thioesterase 7 with CoA==
+<StructureSection load='6vfy' size='340' side='right'caption='[[6vfy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Teakel, S.L., Forwood, J.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6vfy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VFY FirstGlance]. <br>
-Description: Crystal structure of mouse acyl-CoA thioesterase 7 with CoA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2] </span></td></tr>
-[[Category: Forwood, J.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vfy OCA], [http://pdbe.org/6vfy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vfy RCSB], [http://www.ebi.ac.uk/pdbsum/6vfy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vfy ProSAT]</span></td></tr>
-[[Category: Teakel, S.L]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BACH_MOUSE BACH_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.<ref>PMID:11834298</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Palmitoyl-CoA hydrolase]]
+[[Category: Forwood, J K]]
+[[Category: Teakel, S L]]
+[[Category: Coenzyme some]]
+[[Category: Hydrolase]]
+[[Category: Thioesterase]]