6klq: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6klq is ~~ON HOLD until Paper~~ Publication

==Tropomyosin of cardiac thin filament in high-calcium state==

== Structural highlights ==

<table><tr><td colspan='2'>[[6klq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KLQ FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klq OCA], [http://pdbe.org/6klq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klq RCSB], [http://www.ebi.ac.uk/pdbsum/6klq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klq ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Troponin is an essential component of striated muscle and it regulates the sliding of actomyosin system in a calcium-dependent manner. Despite its importance, the structure of troponin has been elusive due to its high structural heterogeneity. In this study, we analyzed the 3D structures of murine cardiac thin filaments using a cryo-electron microscope equipped with a Volta phase plate (VPP). Contrast enhancement by a VPP enabled us to reconstruct the entire repeat of the thin filament. We determined the orientation of troponin relative to F-actin and tropomyosin, and characterized the interactions between troponin and tropomyosin. This study provides a structural basis for understanding the molecular mechanism of actomyosin system.

~~Authors:~~ Oda, T., Yanagisawa, H., Wakabayashi, T.

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.,Oda T, Yanagisawa H, Wakabayashi T J Struct Biol. 2020 Jan 16:107450. doi: 10.1016/j.jsb.2020.107450. PMID:31954841<ref>PMID:31954841</ref>

~~Description: Tropomyosin~~ of ~~cardiac thin filament in high~~-~~calcium state~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased~~ Structures]]

</div>

[[Category: ~~Yanagisawa, H~~]]

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Oda, T]]

[[Category: Wakabayashi, T]]

[[Category: Yanagisawa, H]]

[[Category: Cardiac thin filament]]

[[Category: Contractile protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6klq is ON HOLD  until Paper Publication
+==Tropomyosin of cardiac thin filament in high-calcium state==
+<StructureSection load='6klq' size='340' side='right'caption='[[6klq]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6klq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KLQ FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klq OCA], [http://pdbe.org/6klq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klq RCSB], [http://www.ebi.ac.uk/pdbsum/6klq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klq ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Troponin is an essential component of striated muscle and it regulates the sliding of actomyosin system in a calcium-dependent manner. Despite its importance, the structure of troponin has been elusive due to its high structural heterogeneity. In this study, we analyzed the 3D structures of murine cardiac thin filaments using a cryo-electron microscope equipped with a Volta phase plate (VPP). Contrast enhancement by a VPP enabled us to reconstruct the entire repeat of the thin filament. We determined the orientation of troponin relative to F-actin and tropomyosin, and characterized the interactions between troponin and tropomyosin. This study provides a structural basis for understanding the molecular mechanism of actomyosin system.
-Authors: Oda, T., Yanagisawa, H., Wakabayashi, T.
+Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.,Oda T, Yanagisawa H, Wakabayashi T J Struct Biol. 2020 Jan 16:107450. doi: 10.1016/j.jsb.2020.107450. PMID:31954841<ref>PMID:31954841</ref>
-Description: Tropomyosin of cardiac thin filament in high-calcium state
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Yanagisawa, H]]
+<div class="pdbe-citations 6klq" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
 [[Category: Oda, T]]
 [[Category: Wakabayashi, T]]
+[[Category: Yanagisawa, H]]
+[[Category: Cardiac thin filament]]
+[[Category: Contractile protein]]