6qja: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6qja is ~~ON HOLD until Paper Publication~~

==Crystal structure of the NuMA N-terminal hook domain==

~~Authors~~: ~~Carminati~~, M., ~~Mapelli~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[6qja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJA FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of the ~~NuMA N~~-~~terminal hook domain~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qja OCA], [http://pdbe.org/6qja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qja RCSB], [http://www.ebi.ac.uk/pdbsum/6qja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qja ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Acute promyelocytic leukemia.

== Function ==

[[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.<ref>PMID:19255246</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Carminati, M]]

[[Category: Mapelli, M]]

[[Category: ~~Carminati, M~~]]

[[Category: Hook domain]]

[[Category: Motor protein-associated]]

[[Category: Structural protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qja is ON HOLD  until Paper Publication
+==Crystal structure of the NuMA N-terminal hook domain==
+<StructureSection load='6qja' size='340' side='right'caption='[[6qja]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
-Authors: Carminati, M., Mapelli, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJA FirstGlance]. <br>
-Description: Crystal structure of the NuMA N-terminal hook domain
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qja OCA], [http://pdbe.org/6qja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qja RCSB], [http://www.ebi.ac.uk/pdbsum/6qja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qja ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Acute promyelocytic leukemia.
+== Function ==
+[[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.<ref>PMID:19255246</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Carminati, M]]
 [[Category: Mapelli, M]]
-[[Category: Carminati, M]]
+[[Category: Hook domain]]
+[[Category: Motor protein-associated]]
+[[Category: Structural protein]]