6s21: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6s21 is ~~ON HOLD~~

==Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)==

~~Authors~~: ~~Ndeh~~, D., ~~Basle~~, A., ~~Strahl~~, H., ~~Henrissat~~, B., ~~Terrapon, N~~.~~, Cartmell, A~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6s21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S21 FirstGlance]. <br>

~~Description~~: ~~The metabolism~~ of ~~multiple~~ glycosaminoglycans by the human gut ~~microbiota is orchestrated by a versatile core genetic locus~~ (~~BT33494S-sulf~~)

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s21 OCA], [http://pdbe.org/6s21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s21 RCSB], [http://www.ebi.ac.uk/pdbsum/6s21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s21 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ENDSF_BACTN ENDSF_BACTN]] Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).<ref>PMID:25002587</ref> <ref>PMID:25002587</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Basle, A]]

[[Category: Cartmell, A]]

[[Category: Henrissat, B]]

[[Category: Ndeh, D]]

[[Category: Strahl, H]]

~~[[Category: Henrissat, B]]~~

[[Category: Terrapon, N]]

[[Category: ~~Ndeh, D~~]]

[[Category: Cazyme]]

[[Category: ~~Basle, A~~]]

[[Category: Glycobiology]]

[[Category: Glycosaminoglycan]]

[[Category: Gut microbiota]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6s21 is ON HOLD
+==Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)==
+<StructureSection load='6s21' size='340' side='right'caption='[[6s21]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors: Ndeh, D., Basle, A., Strahl, H., Henrissat, B., Terrapon, N., Cartmell, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6s21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S21 FirstGlance]. <br>
-Description: The metabolism of multiple glycosaminoglycans by the human gut microbiota is orchestrated by a versatile core genetic locus (BT33494S-sulf)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s21 OCA], [http://pdbe.org/6s21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s21 RCSB], [http://www.ebi.ac.uk/pdbsum/6s21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s21 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ENDSF_BACTN ENDSF_BACTN]] Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).<ref>PMID:25002587</ref> <ref>PMID:25002587</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Basle, A]]
 [[Category: Cartmell, A]]
+[[Category: Henrissat, B]]
+[[Category: Ndeh, D]]
 [[Category: Strahl, H]]
-[[Category: Henrissat, B]]
 [[Category: Terrapon, N]]
-[[Category: Ndeh, D]]
+[[Category: Cazyme]]
-[[Category: Basle, A]]
+[[Category: Glycobiology]]
+[[Category: Glycosaminoglycan]]
+[[Category: Gut microbiota]]
+[[Category: Hydrolase]]