6sgl: Difference between revisions
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==Crystal structure of monooxygenase RutA complexed with Uracil under atmospheric pressure.== | |||
<StructureSection load='6sgl' size='340' side='right'caption='[[6sgl]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6sgl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SGL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6sgg|6sgg]], [[6sgj|6sgj]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.46 1.14.99.46] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sgl OCA], [http://pdbe.org/6sgl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sgl RCSB], [http://www.ebi.ac.uk/pdbsum/6sgl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sgl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RUTA_ECOLI RUTA_ECOLI]] Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro.<ref>PMID:16540542</ref> <ref>PMID:20400551</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Matthews, A]] | [[Category: Matthews, A]] | ||
[[Category: Saleem-Batcha, R]] | [[Category: Saleem-Batcha, R]] | ||
[[Category: Teufel, R]] | |||
[[Category: Bioengineering]] | |||
[[Category: Flavin-n5-oxide]] | |||
[[Category: Flavoprotein]] | |||
[[Category: Fmn]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Ruta]] | |||
Revision as of 08:09, 5 February 2020
Crystal structure of monooxygenase RutA complexed with Uracil under atmospheric pressure.
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