Sorting nexin: Difference between revisions
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*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> | *'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> | ||
*'''SNX 16''' has a role in protein transport from early to late endosomes.<br /> | *'''SNX 16''' has a role in protein transport from early to late endosomes.<br /> | ||
*'''SNX 22''', '''SNX 24''' and '''SNX | *'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br /> | ||
*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br /> | *'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br /> | ||
*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br /> | *'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br /> | ||
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== Relevance == | == Relevance == | ||
SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>. | SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>. | ||
==3D structures of sorting nexin== | |||
[[Sorting nexin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*Sorting nexin 3 | *Sorting nexin 3 | ||
**[[2mxc]] – hSNX - NMR <br /> | **[[2mxc]] – hSNX - NMR <br /> | ||
**[[2yps]] – hSNX PX domain <br /> | **[[2yps]] – hSNX PX domain <br /> | ||
**[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br /> | **[[5f0j]] – hSNX PX domain + VPS26 + VPS35<br /> | ||
**[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br /> | **[[5f0l]], [[5f0m]], [[5f0p]] – hSNX + VPS26 + VPS35 + DMT1 peptide<br /> | ||
**[[1ocs]] – ySNX PX domain – yeast<br /> | |||
**[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br /> | |||
*Sorting nexin 5 | *Sorting nexin 5 | ||
**[[5tgh]], [[5tgi]], [[5wy2]] – hSNX PX domain + INCE<br /> | |||
**[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br /> | **[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br /> | ||
**[[5tp1]] – mSNX PX domain + INCE<br /> | **[[5tp1]] – mSNX PX domain + INCE<br /> | ||
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*Sorting nexin 27 | *Sorting nexin 27 | ||
**[[4has]], [[5zn9]] – hSNX PX domain <br /> | |||
**[[6sak]] – hSNX PX domain + otulin<br /> | |||
**[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br /> | **[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal <br /> | ||
**[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br /> | **[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal <br /> | ||
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**[[4p2a]] – rSNX PDZ domain + VPSA26 <br /> | **[[4p2a]] – rSNX PDZ domain + VPSA26 <br /> | ||
**[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br /> | **[[4z8j]] – rSNX PDZ domain + parathyroid hormone receptor PDZ domain <br /> | ||
**[[ | |||
*Sorting nexin 32 | |||
**[[6e8r]] – hSNX PX domain + INCE<br /> | |||
*Sorting nexin 33 | *Sorting nexin 33 | ||
