6pj3: Difference between revisions
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==Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex== | |||
<StructureSection load='6pj3' size='340' side='right'caption='[[6pj3]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6pj3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PJ3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OKY:1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one'>OKY</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-2,3-diacylglucosamine_diphosphatase UDP-2,3-diacylglucosamine diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.54 3.6.1.54] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pj3 OCA], [http://pdbe.org/6pj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pj3 RCSB], [http://www.ebi.ac.uk/pdbsum/6pj3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pj3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A1S0WIC1_KLEPN A0A1S0WIC1_KLEPN]] Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.[HAMAP-Rule:MF_00575][SAAS:SAAS00911811] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: UDP-2,3-diacylglucosamine diphosphatase]] | |||
[[Category: Cho, J]] | |||
[[Category: Zhou, P]] | |||
[[Category: Biosynthetic protein]] | |||
[[Category: Jh-lph-33]] | |||
[[Category: Lipid some]] | |||
[[Category: Lpxh]] | |||
Revision as of 04:19, 13 February 2020
Crystal structure of the Klebsiella pneumoniae LpxH/JH-LPH-33 complex
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