6shu: Difference between revisions
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==Borrelia burgdorferi BmpD nucleoside binding protein bound to adenosine== | |||
<StructureSection load='6shu' size='340' side='right'caption='[[6shu]], [[Resolution|resolution]] 1.43Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6shu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SHU FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6shu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6shu OCA], [http://pdbe.org/6shu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6shu RCSB], [http://www.ebi.ac.uk/pdbsum/6shu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6shu ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Borrelia burgdorferi sensu lato (sl), the causative agent of the tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that Basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system binding to purine nucleosides. Nucleosides are essential for bacterial survival in the host organism and these studies suggest a key role for BmpD in the purine salvage pathway of B. burgdorferi sl. As B. burgdorferi sl lacks the enzymes required for de novo purine synthesis, BmpD may play a vital role in ensuring access to the purines needed for sustaining an infection in the host. Further, we show that although human LB patients develop anti-BmpD antibodies, immunization of mice with BmpD does not confer protection against B. burgdorferi sl infection. | |||
Structural and biomolecular analyses of Borrelia burgdorferi BmpD reveal a substrate-binding protein of an ABC-type nucleoside transporter family.,Cuellar J, Astrand M, Elovaara H, Pietikainen A, Siren S, Liljeblad A, Guedez G, Salminen TA, Hytonen J Infect Immun. 2020 Jan 27. pii: IAI.00962-19. doi: 10.1128/IAI.00962-19. PMID:31988175<ref>PMID:31988175</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6shu" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Astrand, M]] | |||
[[Category: Cuellar, J]] | |||
[[Category: Guedez, G]] | |||
[[Category: Hytonen, J]] | |||
[[Category: Salminen, T A]] | |||
[[Category: Nucleoside]] | |||
[[Category: Purine]] | |||
[[Category: Transport protein]] | |||
[[Category: Transporter]] | |||
Revision as of 04:24, 13 February 2020
Borrelia burgdorferi BmpD nucleoside binding protein bound to adenosine
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