6umg: Difference between revisions
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The | ==Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor== | ||
<StructureSection load='6umg' size='340' side='right'caption='[[6umg]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6umg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UMG FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6umh|6umh]], [[6umi|6umi]], [[6umj|6umj]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6umg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umg OCA], [http://pdbe.org/6umg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6umg RCSB], [http://www.ebi.ac.uk/pdbsum/6umg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6umg ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RAMP1_HUMAN RAMP1_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.<ref>PMID:9620797</ref> [[http://www.uniprot.org/uniprot/CALRL_HUMAN CALRL_HUMAN]] Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:22102369</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mohr, C]] | |||
[[Category: Class b gpcr]] | |||
[[Category: Complex]] | |||
[[Category: Fragment antigen binding]] | |||
[[Category: Membrane protein-immune system complex]] | |||
Revision as of 04:29, 13 February 2020
Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor
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