6vip: Difference between revisions
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==TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008== | |||
<StructureSection load='6vip' size='340' side='right'caption='[[6vip]], [[Resolution|resolution]] 1.36Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6vip]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VIP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QXY:{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone'>QXY</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vip OCA], [http://pdbe.org/6vip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vip RCSB], [http://www.ebi.ac.uk/pdbsum/6vip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vip ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Brown, P J]] | |||
[[Category: Doak, B]] | |||
[[Category: Dong, A]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Gunzburg, M]] | [[Category: Gunzburg, M]] | ||
[[Category: Headey, S]] | [[Category: Headey, S]] | ||
[[Category: Hong, Z]] | [[Category: Hong, Z]] | ||
[[Category: James, L I]] | |||
[[Category: Structural genomic]] | |||
[[Category: The, J]] | [[Category: The, J]] | ||
[[Category: | [[Category: Mfp-6008]] | ||
[[Category: | [[Category: Protein binding]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: Transcription]] | |||
[[Category: Tudor]] | |||
Revision as of 04:31, 13 February 2020
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
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