6jj6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6jj6 is ~~ON HOLD until Feb 25 2021~~

==BRD4 in complex with 500==

~~Authors~~: Xu, J., ~~Chen~~, Y., ~~Jiang~~, F., ~~Zhu~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6jj6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JJ6 FirstGlance]. <br>

~~Description~~: ~~BRD4~~ in ~~complex with 500~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C89:1-methyl-6-(3-(4-methylpiperazine-1-carbonyl)benzyl)-1,2a1,5a,6-tetrahydro-2H-pyrido[3,2 6,7]azepino[4,3,2-cd]isoindol-2-one'>C89</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jj6 OCA], [http://pdbe.org/6jj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jj6 RCSB], [http://www.ebi.ac.uk/pdbsum/6jj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jj6 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Chen, Y]]

[[Category: Jiang, F]]

[[Category: Xu, J]]

[[Category: Zhu, J]]

[[Category: ~~Jiang, F~~]]

[[Category: Brd4]]

[[Category: ~~Chen, Y~~]]

[[Category: Inhibitor]]

[[Category: Signaling protein-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6jj6 is ON HOLD  until Feb 25 2021
+==BRD4 in complex with 500==
+<StructureSection load='6jj6' size='340' side='right'caption='[[6jj6]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Xu, J., Chen, Y., Jiang, F., Zhu, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jj6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JJ6 FirstGlance]. <br>
-Description: BRD4 in complex with 500
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C89:1-methyl-6-(3-(4-methylpiperazine-1-carbonyl)benzyl)-1,2a1,5a,6-tetrahydro-2H-pyrido[3,2 6,7]azepino[4,3,2-cd]isoindol-2-one'>C89</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jj6 OCA], [http://pdbe.org/6jj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jj6 RCSB], [http://www.ebi.ac.uk/pdbsum/6jj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jj6 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Chen, Y]]
+[[Category: Jiang, F]]
 [[Category: Xu, J]]
 [[Category: Zhu, J]]
-[[Category: Jiang, F]]
+[[Category: Brd4]]
-[[Category: Chen, Y]]
+[[Category: Inhibitor]]
+[[Category: Signaling protein-inhibitor complex]]