6lfe: Difference between revisions
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==Rat-COMT, Nitecapone,SAM and Mg bond== | |||
<StructureSection load='6lfe' size='340' side='right'caption='[[6lfe]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lfe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LFE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAO:[5-(2-ethanoyl-3-oxidanylidene-but-1-enyl)-2,3-bis(oxidanyl)phenyl]-oxidanyl-oxidanylidene-azanium'>EAO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lfe OCA], [http://pdbe.org/6lfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lfe RCSB], [http://www.ebi.ac.uk/pdbsum/6lfe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lfe ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Catechol O-methyltransferase]] | |||
[[Category: Large Structures]] | |||
[[Category: Iijima, H]] | |||
[[Category: Suzuki, M]] | |||
[[Category: Takebe, K]] | |||
[[Category: Catecholamine]] | |||
[[Category: Enzyme s-adenosylmethionone catechol]] | |||
[[Category: Transferase]] | |||
