6vsb: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vsb OCA], [http://pdbe.org/6vsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vsb RCSB], [http://www.ebi.ac.uk/pdbsum/6vsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vsb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vsb OCA], [http://pdbe.org/6vsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vsb RCSB], [http://www.ebi.ac.uk/pdbsum/6vsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vsb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
The outbreak of a novel betacoronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development, we determined a 3.5 A-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally, we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to 2019-nCoV S, suggesting antibody cross-reactivity may be limited between the two RBDs. The structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis. | |||
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.,Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS Science. 2020 Feb 19. pii: science.abb2507. doi: 10.1126/science.abb2507. PMID:32075877<ref>PMID:32075877</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 6vsb" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:24, 4 March 2020
Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up
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