5b1z: Difference between revisions
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==Crystal structure of Bcl-xL in complex with HBx-BH3 motif== | ==Crystal structure of Bcl-xL in complex with HBx-BH3 motif== | ||
<StructureSection load='5b1z' size='340' side='right' caption='[[5b1z]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='5b1z' size='340' side='right'caption='[[5b1z]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5b1z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[5b1z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hbv Hbv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1Z FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1z OCA], [http://pdbe.org/5b1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1z RCSB], [http://www.ebi.ac.uk/pdbsum/5b1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1z ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1z OCA], [http://pdbe.org/5b1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1z RCSB], [http://www.ebi.ac.uk/pdbsum/5b1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1z ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/I3XMW8_HBV I3XMW8_HBV]] Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.[RuleBase:RU361181] | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/I3XMW8_HBV I3XMW8_HBV]] Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.[RuleBase:RU361181] | ||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hbv]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Yuan, Y A]] | [[Category: Yuan, Y A]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
Revision as of 08:45, 11 March 2020
Crystal structure of Bcl-xL in complex with HBx-BH3 motif
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