Intrinsically Disordered Protein: Difference between revisions
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* Evasion of immune responses by parasites. Highly flexible disordered proteins are poor antigens <ref>PMID: 23746503</ref>. | * Evasion of immune responses by parasites. Highly flexible disordered proteins are poor antigens <ref>PMID: 23746503</ref>. | ||
==Molecular Shields== | |||
It appears that hundreds of IDPs that remain soluble after boiling protect folded proteins against heat-denaturation, aggregation, and loss of activity from dessication or organic solvents. They also appear to suppress neurodegeneration and extend lifespan. They have been termed "heat-resistant obscure" (hero) proteins. Their isoelectric pH's (pI's) form a bimodal distribution, so that most are negatively or positively charged at neutral pH. In several test cases, scrambling the sequences of these proteins did not diminish their protective effects. Their protective activity appears to depend on their high charge density and length, but not on a specific sequence. | |||
== Protein disorder predictors == | == Protein disorder predictors == | ||
