Sandbox 20001: Difference between revisions
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== Key Sites == | == Key Sites == | ||
* A summary of key findings about [http://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html COVID-19] can be found at [https://www.cdc.gov/ The Centers for Disease Control and Prevention (CDC)] | * A summary of key findings about [http://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html COVID-19] can be found at [https://www.cdc.gov/ The Centers for Disease Control and Prevention (CDC)]. | ||
* A page at PDB-101 on [http://pdb101.rcsb.org/browse/viruses Viruses] shows the relationship of atomic resolution structures of viruses to new avenues for the creation of drugs and vaccines to fight them. | |||
== Recent published papers == | == Recent published papers == | ||
* A study by Zhou & colleagues in ''Science'' on the structural basis for the recognition of the SARS-CoV-2 (COVID-19) by full-length human ACE2 '''gives insights to the molecular basis for coronavirus recognition and infection'''<ref>PMID:32132184</ref>. | * A study by Zhou & colleagues in ''Science'' on the structural basis for the recognition of the SARS-CoV-2 (COVID-19) by full-length human ACE2 '''gives insights to the molecular basis for coronavirus recognition and infection'''<ref>PMID:32132184</ref>. | ||
* A recent study by Gautret ''et al''. (2020) showed, despite its small sample size (20 patients treated), that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.<ref>Gautret, ''et al.'' "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial: Intl J Antimcrob Agents" (in press) 2020 [http://dx.doi.org/10.1016/j.ijantimicag.2020.105949]</ref> | * A recent study by Gautret ''et al''. (2020) showed, despite its small sample size (20 patients treated), that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.<ref>Gautret, ''et al.'' "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial: Intl J Antimcrob Agents" (in press) 2020 [http://dx.doi.org/10.1016/j.ijantimicag.2020.105949]</ref>. | ||
* Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of COVID-19 in China; the summary of some promising results are summarized.<ref>PMID:32147628</ref> | * Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of COVID-19 in China; the summary of some promising results are summarized.<ref>PMID:32147628</ref>. | ||
