User:Holly Rowe/Sandbox 1: Difference between revisions
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==Introduction== | ==Introduction== | ||
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File] | [https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File] | ||
Calcium is a very important signaling molecule in the body with many physiological functions including muscle contraction, neuron excitability, cell migration and growth. The mitochondria are important regulators of calcium in the body and the calcium uniporter (MCU) maintains calcium homeostasis within the mitochondria. Calcium moves in one direction from the intermembrane space through the inner mitochondrial membrane into the matrix. The matrix is more negative driven by the respiratory chain which draws calcium in and allows calcium to move down its gradient. | |||
The MCU is a complex. Its MICU1 and MICU2 bind together and associate with EMRE which regulates MCU. The MICU1 and MICU2 act as gatekeepers. EMRE connects the MICU1 and MICU2 sensors to MCU therefore regulating calcium uptake for the protein | |||
<scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene> | <scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene> | ||
The selectivity pore is an integral part of the protein. This pore contains a group of glutamate with oxygen facing inward forming a carboxylate ring through which calcium enters. This negative carboxylate ring does a good job of pulling the positive calcium into the selectivity pore at the top of the protein. | |||
==Structure== | ==Structure== | ||
