Virus protease

spinqualitylabelsall models Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes. F Disease Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis. Structural highlights Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq). Whole binding site. See also Immunodeficiency virus protease Human Immunodeficiency Virus HIV-1 protease HIV Protease Inhibitor Pharmacokinetics HIV Protease Inhibitor Resistance Profile HIV Protease Resistance Molecular Playground/Dengue Virus Protease Viability of a drug-resistant HIV-1 protease mutant Molecular Playground/Dengue Virus Protease FMDV 3C for Foot-and-Mouth virus protease

3D Structures of Virus proteases

Updated on 27-March-2020

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• HIV-1 protease . See 1cqq
• HIV-2 protease See Immunodeficiency virus protease
• Feline Immunodeficiency virus protease See Human Immunodeficiency Virus

• Simian Immunodeficiency virus protease See HIV-1 protease
• Xenotropic murine leukemia virus protease
  • HIV Protease Inhibitor Pharmacokinetics – XMRV-PR P14
    
  • HIV Protease Inhibitor Resistance Profile – XMRV-PR RNase H domain (mutant)
    
  • HIV Protease Resistance – XMRV-PR residues 533-657 + inhibitor
    
  • Molecular Playground/Dengue Virus Protease – XMRV-PR residues 533-657 + pepstatin
    
  • Viability of a drug-resistant HIV-1 protease mutant – XMRV-PR residues 533-657 + amprenavir
    
• Human T-cell leukemia virus protease
  • Molecular Playground/Dengue Virus Protease – HTLV-PV + peptide
    
  • FMDV 3C, 3liq, 3lit, 3liv, 3lix, 3liy, 4ydg, 4ydf – HTLV-PV (mutant) + inhibitor
    
• Rous sarcoma virus protease
  • 2rsp – RSVP - Rous sarcoma virus
    
  • 1bai – RSVP + polypeptide inhibitor
• Human Cytomegalovirus protease
  • 1wpo – CMVP - human herpes virus 5
    
  • 1cmv, 1lay, 1jq6, 1id4, 1iec, 1ied, 1ief, 1ieg – CMVP (mutant)
    
  • 2wpo, 1jq7 - CMVP (mutant) + inhibitor
    
  • 1njt, 1nju, 1nkk, 1nkm - CMVP (mutant) + peptide inhibitor
    
• Varicella-Zoster virus protease
  • 1vzv - VZVP (mutant) – human herpes virus
• Equine infectious anemia virus protease
  • 2fmb, 1fmb – EIAVP (mutant) + inhibitor
• Hepatitis A virus protease
  • 1hav – HAVP (mutant) – hepatitis A virus
    
  • 2h9h, 2hal – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
    
  • 2h6m – HAVP + peptide inhibitor
    
  • 1qa7, 3r0f – HAVP (mutant) + inhibitor
    
• Hepatitis C virus protease
  • 2o8m – HCVP (mutant)
    
  • 2a4g, 2gvf, 2f9u, 2f9v – HCVP + peptide inhibitor
    
  • 6nzt, 6nzv – HCVP (mutant) + inhibitor
    
• Orf 17
  • 3njq – hOrf 17 - human herpes virus 8
• Dengue virus protease
  • 3u1i – DvNs2b + peptide – Dengue virus
    
  • 3u1j – DvNs2b + BPTI
    
  • 2fom - DvNs2b/DvNs3
    
  • 4m9f, 4m9i, 4m9k, 4m9m, 3lkw - DvNs2b/DvNs3 (mutant)
    
  • 6mo0, 6mo1, 6mo2 - DvNs2b residues 1394-1440 + inhibitor
    
  • 4m9t - DvNs2b/DvNs3 (mutant) + inhibitor
    
  • 2jlq – DvNs3 residues 1646-2092
    
  • 2jlv – DvNs3 residues 1646-2092 + AMPPNP + RNA
    
  • 2jlr – DvNs3 residues 1646-2092 + AMPPNP
    
  • 2jls – DvNs3 residues 1646-2092 + ADP
    
  • 2jlx, 2jly, 2jlz – DvNs3 residues 1646-2092 + ADP + RNA
    
  • 2jlu, 2jlw – DvNs3 residues 1646-2092 + RNA
    
  • 2vbc, 2whx, 2wzq – DvNs3 residues 1475-2092 + peptide inhibitor
    
  • 2m9p, 2m9q – DvNs3 residues 1475-1648 + peptide inhibitor - NMR
    
• Herpes simplex virus protease
  • 1at3 – HSV II – human herpesvirus 2
• Foot-and-Mouth Disease virus protease
  • 2bhg – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus
    
  • 2jqf, 2j92, 5hm2 – FMDV (mutant)
    
  • 2wv4, 2wv5 – FMDV (mutant) + peptide
    
• Infectious Bronchitis virus protease
  • 2q6d, 4x2z – IBV – infectious bronchitis virus
    
  • 2q6f – IBV + inhibitor
• Yellowtail ascites virus protease
  • 4cx8, 4b07, 4b0t – YAV – yellowtail ascites virus
    
  • 4b08 – YAV + inhibitor
    
  • 4izj, 4izk – YAV Vp4 (mutant)
• Yellow fever virus protease
  • 6urv – NS2B + NS3
    
• Zika virus protease
  • 6um3 – NS2B + NS3
    
• Pseudorabies virus protease
  • 4cx8 – YAV – pseudorabies virus
    
• Coxsakievirus protease
  • 2vb0, 2zty, 2ztz, 3zyd, 3sj8 – CSVP
    
  • 2zu1, 3zye, 3zz3, 3zz4 – CSVP (mutant)
    
  • 2ztx – CSVP + Zn-H2S
    
  • 2zu3, 3zz5, 3zz6, 3zz7, 3zz8, 3zz9, 3zza, 3zzb, 3sji – CSVP + inhibitor
    
  • 3zzc, 3zzd – CSVP (mutant) + inhibitor
    
  • 3sj9 – CSVP (mutant) + peptide inhibitor
    
• Human polio virus protease
  • 1l1n – HPV
    
  • 2ijd – HPV (mutant)
    
• Human rhinovirus protease
  • 2in2 – HRVP – human rhinovirus - NMR
    
  • 1cqq, 2xya, 5fx5, 5fx6, 6ffn, 6ffs – HRVP + inhibitor
    
  • 2b0f – HRVP + inhibitor – NMR
    
  • 2h6m – HRVP + peptide inhibitor
    
• Human enterovirus protease
  • 3osy – HEVP 71 – human enterovirus
    
  • 3zv8 – HEVP 68 residues 1549-1731
    
  • 3q3x – HEVP B (mutant)
    
  • 3q3y – HEVP B (mutant) + inhibitor
    
  • 3ruo – HEVP B + inhibitor
    
  • 3sjk – HEVP 71 (mutant) + peptide inhibitor
    
  • 3sjo, 5bpe, 5hxf, 5wq2 – HEVP 71 + inhibitor
    
  • 3qzq, 3qzr – HEVP 71 (mutant) + inhibitor
    
  • 3zv9, 3zva, 3zvb, 3zvc, 3zvd, 3zve, 3zvf, 3zvg – HEVP 68 + inhibitor
    
• Porcine epidemic diarrhea virus protease
  • 5hyo – PEDVP – porcine epidemic diarrhea virus
    
• Coronavirus protease
  • 4wme, 4wmf – CVP (mutant)- coronavirus
    
• SARS coronavirus protease
  • 3e91, 3ea7, 3ea8, 3ea9, 3eaj – SCVP (mutant) – SARS coronavirus
    
  • 2amd, 2amq, 2gx4, 2z9g, 2z9j, 2z9k, 2z9l, 2zu5, 4mds, 4tww, 4twy – SCVP + inhibitor
    
• SARS COV-19 protease
  • 6lu7 – COV-19 + inhibitor
    
• Murine coronavirus protease
  • 6jij – MCP + peptide inhibitor
    
• Coronavirus HKU4 protease
  • 2ynb – CVHP + inhibitor – BAT coronavirus
    
• Echovirus 1 protease
  • 5iyt – EV1P (mutant) + inhibitor – Echovirus 1
    
• Norovirus protease
  • 5e0g, 5e0h, 5e0j – NVP (mutant)+ peptide inhibitor – Norovirus
    
  • 3ur9, 4imq, 4xbb, 4xbc, 4xbd, 5dg6, 5dgj, 5tg1, 5tg2 – NVP residues 1101-1281 + inhibitor
    
• Norovirus 3C-like protease
  • 1wqs – NVLP – chiba virus
    
• Gastroentritis virus protease
  • 2amp – GEVP + inhibitor – gastroenteritis virus
    
• Southampton virus protease
  • 2iph – SVP + inhibitor – Southampton virus
    
• West Nile virus protease
  • 2ggv - WNVP (mutant) - West Nile virus
    
  • 2ijo - WNVP (mutant) + BPTI
    
  • 2yol, 5idk, 2fp7 - WNVP + peptide inhibitor
    
  • 3e90 - WNVP + inhibitor
    
• African swine fever virus protease
  • 6ljb, 6lj9 – ASFV – African swine fever virus
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman