6jka: Difference between revisions
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==Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor== | |||
<StructureSection load='6jka' size='340' side='right'caption='[[6jka]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jka]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQU:3-[2-azanyl-5-[2-(phenoxymethyl)-1,3-thiazol-4-yl]phenyl]propanoic+acid'>BQU</scene>, <scene name='pdbligand=BS0:6-[2-(phenoxymethyl)-1,3-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one'>BS0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jka OCA], [http://pdbe.org/6jka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jka RCSB], [http://www.ebi.ac.uk/pdbsum/6jka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jka ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Large Structures]] | |||
[[Category: Fudo, S]] | |||
[[Category: Hayashi, U]] | |||
[[Category: Hoshino, T]] | |||
[[Category: Kamo, T]] | [[Category: Kamo, T]] | ||
[[Category: Kondo, S]] | [[Category: Kondo, S]] | ||
[[Category: Kuroda, K]] | |||
[[Category: Nukaga, M]] | [[Category: Nukaga, M]] | ||
[[Category: | [[Category: Hydrolase]] | ||
Revision as of 10:02, 27 March 2020
Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor
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