6vyc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6vyc is ~~ON HOLD~~

==Crystal structure of WD-repeat domain of human WDR91==

~~Authors~~: ~~Halabelian~~, L., ~~Hutchinson~~, A., Li, Y., ~~Seitova, A~~., ~~Bountra~~, C., ~~Edwards, A~~.M., Arrowsmith, C.H., ~~Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6vyc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VYC FirstGlance]. <br>

~~Description~~: ~~Crystal structure of WD-repeat domain of human WDR91~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyc OCA], [http://pdbe.org/6vyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyc RCSB], [http://www.ebi.ac.uk/pdbsum/6vyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyc ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN]] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Halabelian, L]]

[[Category: Hutchinson, A]]

[[Category: ~~Arrowsmith~~, ~~C.H~~]]

[[Category: Li, Y]]

[[Category: Structural genomic]]

[[Category: Seitova, A]]

[[Category: ~~Li, Y~~]]

[[Category: Protein transport]]

[[Category: ~~Halabelian, L~~]]

[[Category: Sgc]]

[[Category: ~~Edwards, A.M]]~~

[[Category: Wd-repeat]]

~~[[Category: Structural Genomics Consortium (Sgc)~~]]

[[Category: Wdr91]]

[[Category: ~~Bountra, C~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6vyc is ON HOLD
+==Crystal structure of WD-repeat domain of human WDR91==
+<StructureSection load='6vyc' size='340' side='right'caption='[[6vyc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Halabelian, L., Hutchinson, A., Li, Y., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6vyc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VYC FirstGlance]. <br>
-Description: Crystal structure of WD-repeat domain of human WDR91
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vyc OCA], [http://pdbe.org/6vyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vyc RCSB], [http://www.ebi.ac.uk/pdbsum/6vyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vyc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN]] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Halabelian, L]]
 [[Category: Hutchinson, A]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Li, Y]]
+[[Category: Structural genomic]]
 [[Category: Seitova, A]]
-[[Category: Li, Y]]
+[[Category: Protein transport]]
-[[Category: Halabelian, L]]
+[[Category: Sgc]]
-[[Category: Edwards, A.M]]
+[[Category: Wd-repeat]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Wdr91]]
-[[Category: Bountra, C]]