Sandbox Reserved 1606: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Sandbox_Reserved_CH462_Biochemistry_II}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | |||
==ABCG2 Multidrug Transporter== | ==ABCG2 Multidrug Transporter== | ||
<StructureSection load='5nj3' size='350' side='right' caption='ABCG2 Multidrug Transporter with Fab Fragments' scene=''> | <StructureSection load='5nj3' size='350' side='right' caption='ABCG2 Multidrug Transporter with Fab Fragments' scene=''> | ||
== | ==Background== | ||
The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, blood-testis, and maternal-fetal barriers.<ref name="Taylor"/> ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.<ref name="Manolaridis"/> | The [https://en.wikipedia.org/wiki/ABCG2 ABCG2 multidrug transporter] is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, blood-testis, and maternal-fetal barriers.<ref name="Taylor"/> ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.<ref name="Manolaridis"/> | ||
== Structural highlights == | == Structural highlights == | ||
| Line 34: | Line 31: | ||
===ATP Bound and Unbound Conformations=== | ===ATP Bound and Unbound Conformations=== | ||
===Cavities and Lysine Plug=== | ===Cavities and Lysine Plug=== | ||
==Disease== | ==Disease== | ||
