Sandbox Reserved 1626: Difference between revisions

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Therefore, certain issues with the MCU that cause an imbalance in mitochondrial calcium can lead to heart failure.  Additionally, even if there is nothing wrong with the MCU, it can have an impact in conditions like IRI.  This makes the MCU an interesting target for therapies for both cardiac conditions and many other ailments.
Therefore, certain issues with the MCU that cause an imbalance in mitochondrial calcium can lead to heart failure.  Additionally, even if there is nothing wrong with the MCU, it can have an impact in conditions like IRI.  This makes the MCU an interesting target for therapies for both cardiac conditions and many other ailments.


=== Cancer ===
Cancer is another condition that can impacted by the MCU, though not much is known about the exact mechanisms.  It has mostly been studied in the context of breast and colorectal cancers.  Overexpression or overactivation of the MCU complex was shown to promote cancer proliferation.  Additionally, the overexpression of MICU1 and MICU2 was shown to decrease mitochondrial calcium levels and prevent apoptosis in cancer cells.<ref name="Woods" />  Again, not much is known about the connection between the MCU and cancer cell growth, but the MCU's control over apoptosis and cell growth indicates that mitochondrial calcium regulation is fundamental to cancer cell growth and migration.


== Regulation/Inhibition ==
== Regulation/Inhibition ==
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