Sandbox Reserved 1613: Difference between revisions
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These two domains contain the active site of this transporter protein. The interest in this protein is in its involvement with mutidrug resistant cancer cells. This involvement is due to its active site's promiscuity as many xenobiotics have been found to transported to the outside of the cell by this transporter. | These two domains contain the active site of this transporter protein. The interest in this protein is in its involvement with mutidrug resistant cancer cells. This involvement is due to its active site's promiscuity as many xenobiotics have been found to transported to the outside of the cell by this transporter. | ||
==Function== | ==Function== | ||
[https://www-sciencedirect-com.ezproxy.butler.edu/science/article/pii/S0304383505003538] | |||
ABCG2 transports a variety of substrates, particularly flat, hydrophobic, and/or polycylic molecules. It is found in different biological membranes, such as the blood-brain barrier (BBB), blood-testis barrier, and the blood-placental barrier. It is thought to help protect those tissues and many others from cytotoxins. In addition to cytotoxin protection, ABCG2 secretes endogenous substrates in the adrenal gland, excretes toxins in the liver and kidneys, and regulates absorption of substrates. | |||
== Disease == | == Disease == | ||
Multidrug resistant cancers are due to ABCG2 excreting cancer drugs out of the cell before they have the chance to kill the cell. Some of these cancers include breast, ovarian, and lung. | Multidrug resistant cancers are due to ABCG2 excreting cancer drugs out of the cell before they have the chance to kill the cell. Some of these cancers include breast, ovarian, and lung. | ||
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<ref name="Manolaridis">PMID:30405239</ref> | <ref name="Manolaridis">PMID:30405239</ref> | ||
<ref name="Taylor">PMID:28554189</ref> | <ref name="Taylor">PMID:28554189</ref> | ||
<ref name="Fetsch">PMID:15990223</ref> | |||
<References/> | <References/> | ||
==Student Contributors== | ==Student Contributors== | ||
