User:Madison Summers/Sandbox 1: Difference between revisions

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== Structural highlights and mechanism ==
== Structural highlights and mechanism ==
The MCU is a dimer of dimers, described as tetrameric truncated pyramid.  The uniporter has only a single strong binding site located in the selectivity pore with specificity for [https://en.wikipedia.org/wiki/Calcium_signaling Calcium], near the surface of the inner mitochondrial membrane.  Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm enters the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:structure.png|300 px|right|thumb|Figure 2]]
The MCU is a dimer of dimers, described as tetrameric truncated pyramid.  The uniporter has only a single strong binding site located in the selectivity pore with specificity for [https://en.wikipedia.org/wiki/Calcium_signaling Calcium], near the surface of the inner mitochondrial membrane.  Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm enters the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. [[Image:structure.png|300 px|right|thumb|Figure 2]]


===Transmembrane Domain===
===Transmembrane Domain===
 
The transmembrane domain is in the inner mitochondrial membrane open to the inner membrane space. The small pore, highly specific for calcium binding is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 (transmembrane 2) while TM 1 (transmembrane 1) surrounds the pore. The transmembrane domain exhibits four fold rotational symmetry. The domain swapping of TM1 of one subunit with the TM2 of the neighboring subunits allows for a tight packing in the transmembrane connectivity. It is important that the selectivity pore is small, allowing only a dehydrated calcium molecule to interact with the 5 ampler wide glutamate ring.  
The transmembrane domain is in the inner mitochondrial membrane open to the inner membrane space. The small pore, highly specific for calcium binding is located in the <scene name='83/837230/Transmembrane_domain/1'>transmembrane domain</scene>, in TM2 (transmembrane 2) while TM 1 (transmembrane 1) surrounds the pore. The transmembrane domain exhibits four fold rotational symmetry. The domain swapping of TM1 of one subunit with the TM2 of the neighboring subunits allows for a tight packing in the transmembrane connectivity. It is important that the selectivity pore is small, allowing only a dehydrated calcium molecule to interact with the 5 ampler wide glutamate ring.  


===Coiled coil===
===Coiled coil===
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