Condensin: Difference between revisions

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~~==Your Heading Here (maybe something like 'Structure')==~~

~~This is a default text for your page '''Condensin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~

~~You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~

== Function ==

'''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>.

== Disease ==

== Relevance ==

SMC plays important role in human disease and bacterial pathogenicity and its inhibitors are studied for therapeutic purposes<ref>PMID:30346684</ref>.

== Structural highlights ==

~~This~~ is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

SMC is a multisubunit complex.

</StructureSection>

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

*Condensin or Structural Maintenance of Chromosome Protein

*Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186

[[4u4p]] – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human

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[[6qj0]], [[6qj1]] – CtSMC head domain

[[6qj2]] – CtSMC head domain + Brn1

[[3zgx]] – BsSMC head domain ~~residues 1-219, 983-1186~~ + segregation and condensation protein – ''Bacillus subtilis''

[[3zgx]] – BsSMC head domain + segregation and condensation protein – ''Bacillus subtilis''

[[5xg3]] – BsSMC head domain ~~residues 1-219, 983-1186~~ (mutant)+ coiled-coil domain + segregation and condensation protein

[[5xg3]] – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein

[[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''

[[1xex]] – PfSMC head domain (mutant)

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[[5xei]] – PySMC head+coiled-coil domains –

*Structural Maintenance of Chromosome-related Protein or Chromosome partition protein

**[[2wmm]] – EcMukB hinge domain 645-804 (mutant) - ''Escherichia coli''

**[[4mn4]] – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A

== References ==

Condensin: Difference between revisions

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@@ Line 1: / Line 1: @@
-==Your Heading Here (maybe something like 'Structure')==
 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page '''Condensin'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
+'''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome.  SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>.
 == Disease ==
 == Relevance ==
+SMC plays important role in human disease and bacterial pathogenicity and its inhibitors are studied for therapeutic purposes<ref>PMID:30346684</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+SMC is a multisubunit complex.
 </StructureSection>
@@ Line 19: / Line 21: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-*Condensin or Structural Maintenance of Chromosome Protein
+*Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186
 [[4u4p]] – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human <br />
@@ Line 32: / Line 34: @@
 [[6qj0]], [[6qj1]] – CtSMC head domain <br />
 [[6qj2]] – CtSMC head domain + Brn1<br />
-[[3zgx]] – BsSMC head domain residues 1-219, 983-1186 + segregation and condensation protein – ''Bacillus subtilis''<br />
+[[3zgx]] – BsSMC head domain + segregation and condensation protein – ''Bacillus subtilis''<br />
-[[5xg3]] – BsSMC head domain residues 1-219, 983-1186 (mutant)+ coiled-coil domain + segregation and condensation protein <br />
+[[5xg3]] – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein <br />
 [[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''<br />
 [[1xex]] – PfSMC head domain (mutant)<br />
@@ Line 41: / Line 43: @@
 [[5xei]] – PySMC head+coiled-coil domains – <br />
+*Structural Maintenance of Chromosome-related Protein or Chromosome partition protein
+**[[2wmm]] – EcMukB hinge domain 645-804 (mutant) - ''Escherichia coli'' <br />
+**[[4mn4]] – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A <br />
 == References ==