Condensin

spinqualitylabelsall models Yeast SMC subunit 2 (green) and subunit 3 (grey) complex with DNA (PDB code 5oqn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Condensin or structural maintenance of chromosome protein (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation. SMC exhibits the ability to super-coil DNA. SMC of E. coli is named MukB or Chromosome partition protein A. MukE and MukF are associated with MukB. SMC is found in species from bacteria to human. SMC and cohesin which share structural similarities, are essential for separting the genome into daughter cells during cell division. SMC reorganizes chromsomes into their compact mitotic structure while cohesin glues replicated sister chromatids together until they split at anaphase. Relevance SMC plays important role in human disease and bacterial pathogenicity and its inhibitors are studied for therapeutic purposes. Mutations or removal of SMC subunits cause errors in chromosome segregation and likely cell death. Structural highlights SMC is a multisubunit complex. In vertebrates condensin complex is formed from the association of SMC2 and SMC4 subunits. SMC2 and SMC4 contain 3 domains: head domain forming anATPase, a long coiled-coil region and a hinge domain which facilitates SMC2/SMC4 dimerization.

3D Structures of condensin

Updated on 04-April-2020

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• Condensin or Structural Maintenance of Chromosome Protein; Domains - head 1-219+983-1186
  • 4u4p – hSMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – human
    
  • 6igx – hSMC subunit 2+3
    
  • 3l51 – SMC2 hinge domain 506-666 + SMC4 hinge domain 595-752 – mouse
    
  • 5oqq – ySMC subunit 2+3 – yeast
    
  • 5oqn, 5oqo, 5oqp – ySMC subunit 2+3 + DNA
    
  • 5oqr – SMC subunit 2+3 – fission yeast
    
  • 6q6e – CtSMC residues 112-209 – Chaetomium thermophilum - NMR
    
  • 6qj3 – CtSMC subunit 1+2 + Brn1
    
  • 6qj4 – CtSMC subunit 1+2 + Brn1 + protein
    
  • 6qj0, 6qj1 – CtSMC head domain
    
  • 6qj2 – CtSMC head domain + Brn1
    
  • 3zgx – BsSMC head domain + segregation and condensation protein – Bacillus subtilis
    
  • 5xg3 – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein + ATPγS
    
  • 1xew – PfSMC head domain – Pyrococcus furiosus
    
  • 1xex – PfSMC head domain (mutant)
    
  • 4i99 – PfSMC head domain residues 1-182, 1006-1176 + protein
    
  • 5xns – PfSMC head domain residues 1-219, 983-1186 + segregation and condensation protein
    
  • 5xg2 – PySMC coiled-coil domain – Pyrococcus yayanosii
    
  • 5xei – PySMC head+coiled-coil domains –
    
• Structural Maintenance of Chromosome-related Protein or Chromosome partition protein
  • 2wmm – EcMukB hinge domain 645-804 (mutant) - Escherichia coli
    
  • 4mn4 – EcMukB hinge domain 645-804 * DNA topoisomerase 4 subunit A
    
  • 6h2x, 3ibp – EcMukB coiled-coil domain
    
  • 1qhl – EcMukB N-terminal 1-227
    
  • 3rpu – EcMukE N-terminal * MukF N-terminal
    
  • 3euj, 3euk – MukB head domain (mutant) * MukF residues 292-443 + ATPγS - Haemophilus ducreyi
    

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Michal Harel