Sandbox Reserved 1619: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Layla Wisser (talk | contribs) No edit summary |
Layla Wisser (talk | contribs) No edit summary |
||
| Line 14: | Line 14: | ||
Presenilin (PS1) serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic cleavage is located between TM6 and TM7 in PS1 and major conformational changes take place in this subunit upon substrate binding. | Presenilin (PS1) serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic cleavage is located between TM6 and TM7 in PS1 and major conformational changes take place in this subunit upon substrate binding. | ||
Anterior pharynx-defective 1 (APH-1) serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1 | Anterior pharynx-defective 1 (APH-1) serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1 | ||
Activation of the active site is dependent on the binding of Presenilin enhancer 2 (PEN-2). PEN-2 is also important in maturation of the enzyme. | Activation of the active site is dependent on the binding of Presenilin enhancer 2 (PEN-2). PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref> | ||
