Sandbox Reserved 1619: Difference between revisions
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<scene name='83/832945/Ps1_subunit/1'>Presenilin</scene> serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between TM6 and TM7 in PS1 and major conformational changes take place in this subunit upon substrate binding. | <scene name='83/832945/Ps1_subunit/1'>Presenilin</scene> serves as the active site of the protease and contains 9 TMs, each varying in length. The site of autocatalytic [https://en.wikipedia.org/wiki/Bond_cleavage cleavage] is located between TM6 and TM7 in PS1 and major conformational changes take place in this subunit upon substrate binding. | ||
Anterior pharynx-defective 1 serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1 | Anterior pharynx-defective 1 serves as a scaffold for anchoring and supporting the flexible conformational changes of PS1 | ||
Activation of the active site is dependent on the binding of Presenilin enhancer 2. PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref> | Activation of the active site is dependent on the binding of <scene name='83/832945/Pen2_subunit/1'>Presenilin enhancer 2.</scene> PEN-2 is also important in maturation of the enzyme.<ref name="Yang">PMID:28628788</ref> | ||
