Sandbox Reserved 1613: Difference between revisions
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== Relevance == | == Relevance == | ||
Due to ABCG2 excreting xenobiotics from the cell, they also transport essential cancer drugs out of the cell. By utilizing certain inhibitors (5D3 and <scene name='83/832939/Abcg2_bound_to_mz29/3'>MZ29</scene>), it is possible to shut down these transporters in order to get cancer drugs to remain in and apoptosis the cell. However, this could have residual effects on the excretory system as ABCG2 would no longer be able to excrete anything from the cell, including those detrimental to the body. | Due to ABCG2 excreting xenobiotics from the cell, they also transport essential cancer drugs out of the cell. By utilizing certain inhibitors (<scene name='83/832939/5d3-fab/1'>5D3</scene> and <scene name='83/832939/Abcg2_bound_to_mz29/3'>MZ29</scene>), it is possible to shut down these transporters in order to get cancer drugs to remain in and apoptosis the cell. However, this could have residual effects on the excretory system as ABCG2 would no longer be able to excrete anything from the cell, including those detrimental to the body. | ||
== Structural highlights == | == Structural highlights == | ||
[[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure 2]] | [[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure 2]] | ||
