Sandbox Reserved 1613: Difference between revisions
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== Relevance == | == Relevance == | ||
Due to ABCG2 excreting xenobiotics from the cell, they also transport essential cancer drugs out of the cell. By utilizing certain | Due to ABCG2 excreting xenobiotics from the cell, they also transport essential cancer drugs out of the cell. By utilizing certain binders (<scene name='83/832939/5d3-fab/2'>5D3</scene>, it is able to be stabilized for crystallographic imaging. This has allowed researchers in the past decade to make advances based upon the greater understanding of its structure. Competitive inhibitors such as <scene name='83/832939/Abcg2_bound_to_mz29/3'>MZ29</scene>) have been developed making it possible to shut down these transporters in order to get cancer drugs to remain in and cause apoptosis in the reference cells. However, this could have residual effects on the excretory system as ABCG2 would no longer be able to excrete anything from the particular cells inhibited, including those detrimental to the body. This has caused ABCG2 disfunction to be linked to gout, among other disorders. | ||
== Structural highlights == | == Structural highlights == | ||
[[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure 2]] | [[Image:Ligand_Interactions_6ffc.png|400 px|right|thumb|Figure 2]] | ||
