5qxt: Difference between revisions
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==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with JKH47== | |||
<StructureSection load='5qxt' size='340' side='right'caption='[[5qxt]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qxt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5QXT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RJ7:ethyl+(2S,3S)-2-fluoro-3-hydroxy-3-(pyridin-3-yl)propanoate'>RJ7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5qxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxt OCA], [http://pdbe.org/5qxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qxt RCSB], [http://www.ebi.ac.uk/pdbsum/5qxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adenosinetriphosphatase]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Collins, P]] | |||
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
[[Category: | [[Category: Fowley, D]] | ||
[[Category: Nelson, A]] | |||
[[Category: Snee, M]] | [[Category: Snee, M]] | ||
[[Category: Talon, R]] | [[Category: Talon, R]] | ||
[[Category: Von-Delft, F]] | [[Category: Von-Delft, F]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Pandda]] | |||
[[Category: Sgc - diamond i04-1 fragment screening]] | |||
[[Category: Xchemexplorer]] | |||
Revision as of 06:45, 8 April 2020
PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with JKH47
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