6tgg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 6tgg~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6tgg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TGG FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N8W:~{N}-[(6~{S},7~{R},8~{S},8~{a}~{R})-7,8-bis(oxidanyl)-3-oxidanylidene-1,5,6,7,8,8~{a}-hexahydro-[1,3]oxazolo[3,4-a]pyridin-6-yl]ethanamide'>N8W</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgg OCA], [http://pdbe.org/6tgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tgg RCSB], [http://www.ebi.ac.uk/pdbsum/6tgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgg ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN]] Note=MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence (PubMed:20816948). Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes.

== Function ==

[[http://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN]] The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref> The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Avenoza, A]]

[[Category: Bermejo, I A]]

[[Category: Bernardes, G J.L]]

[[Category: Busto, J H]]

[[Category: Castro-Lopez, J]]

[[Category: Corzana, F]]

[[Category: Garcia-Fernandez, J M]]

[[Category: Garcia-Martin, F]]

[[Category: Guerreiro, A]]

[[Category: Hurtado-Guerrero, R]]

[[Category: Navo, C D]]

[[Category: Nishimura, S I]]

[[Category: Ortiz-Mellet, C]]

[[Category: Peregrina, J M]]

[[Category: Samchez-Fernandez, E M]]

[[Category: Anti cancer vaccine]]

[[Category: Antibody]]

[[Category: Antigen tn]]

[[Category: Antitumor protein]]

[[Category: Conformational analysis]]

[[Category: Iminosugar]]

[[Category: Scfv]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6tgg is ON HOLD  until Paper Publication
+==scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar==
+<StructureSection load='6tgg' size='340' side='right'caption='[[6tgg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6tgg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TGG FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N8W:~{N}-[(6~{S},7~{R},8~{S},8~{a}~{R})-7,8-bis(oxidanyl)-3-oxidanylidene-1,5,6,7,8,8~{a}-hexahydro-[1,3]oxazolo[3,4-a]pyridin-6-yl]ethanamide'>N8W</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgg OCA], [http://pdbe.org/6tgg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tgg RCSB], [http://www.ebi.ac.uk/pdbsum/6tgg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgg ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN]] Note=MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence (PubMed:20816948). Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes.
+== Function ==
+[[http://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN]] The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref>   The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Avenoza, A]]
+[[Category: Bermejo, I A]]
+[[Category: Bernardes, G J.L]]
+[[Category: Busto, J H]]
+[[Category: Castro-Lopez, J]]
+[[Category: Corzana, F]]
+[[Category: Garcia-Fernandez, J M]]
+[[Category: Garcia-Martin, F]]
+[[Category: Guerreiro, A]]
+[[Category: Hurtado-Guerrero, R]]
+[[Category: Navo, C D]]
+[[Category: Nishimura, S I]]
+[[Category: Ortiz-Mellet, C]]
+[[Category: Peregrina, J M]]
+[[Category: Samchez-Fernandez, E M]]
+[[Category: Anti cancer vaccine]]
+[[Category: Antibody]]
+[[Category: Antigen tn]]
+[[Category: Antitumor protein]]
+[[Category: Conformational analysis]]
+[[Category: Iminosugar]]
+[[Category: Scfv]]