Sandbox Reserved 895: Difference between revisions
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= '''[1] Introduction''' = | = '''[1] Introduction''' = | ||
<StructureSection load='4rsc' size=' | <StructureSection load='4rsc' size='350' frame='false' align='center' caption='Figure 1A: 3-dimensional binding site of bovine RPE65 with (R)-Emixustat and palmitate' scene=''> | ||
In humans the vertebrate vision is maintained by a chemical process known as the retinoid (visual) cycle. This cycle is a complex enzymatic pathway that operates within the retina to regenerate a key visual chromophore known as 11-''cis''-retinal. The enzyme responsible for regenerating the key visual chromophore, 11-''cis''-retinal is a microsomal membrane protein retinal pigment epithelium 65 also known as RPE65. The RPE65 enzyme catalyzes the chemical conversion of all-''trans''-retinyl ester (or all-''trans''-retinyl palmityl ester) to 11-''cis''-retinol within the human retinal pigment epithelium (hRPE). <ref>DOI 19805034 </ref> | In humans the vertebrate vision is maintained by a chemical process known as the retinoid (visual) cycle. This cycle is a complex enzymatic pathway that operates within the retina to regenerate a key visual chromophore known as 11-''cis''-retinal. The enzyme responsible for regenerating the key visual chromophore, 11-''cis''-retinal is a microsomal membrane protein retinal pigment epithelium 65 also known as RPE65. The RPE65 enzyme catalyzes the chemical conversion of all-''trans''-retinyl ester (or all-''trans''-retinyl palmityl ester) to 11-''cis''-retinol within the human retinal pigment epithelium (hRPE). <ref>DOI 19805034 </ref> | ||
