ACE2/structural biology project: Difference between revisions
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== ACE2 as a microbal entry receptor == | == ACE2 as a microbal entry receptor == | ||
<Structure load='2AJF' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | |||
As a membrane protein, ACE2 serves as a functional receptor for coronaviruses, including SARS-CoV<ref>PMID:25720466</ref>, SARS-CoV-2(causes COVID19)<ref>DOI: 10.1126/science.abb2762</ref> and HCoV-NL63. S protein, also known as spike glycoprotein, mediates receptor recognition and fusion of the membrane<ref>PMID:24121034</ref>. During infection the cleavage of the S protein produces S1 and S2 subunits. S1 contains the receptor binding domain (RBD) and directly binds to the peptidase domain of ACE2 on the surface of cells. This spiking results in endocytosis and translocation of both virus and the enzyme, where S2 is responsible for the membrane fusion<ref>PMID:18227861</ref>. | As a membrane protein, ACE2 serves as a functional receptor for coronaviruses, including SARS-CoV<ref>PMID:25720466</ref>, SARS-CoV-2(causes COVID19)<ref>DOI: 10.1126/science.abb2762</ref> and HCoV-NL63. S protein, also known as spike glycoprotein, mediates receptor recognition and fusion of the membrane<ref>PMID:24121034</ref>. During infection the cleavage of the S protein produces S1 and S2 subunits. S1 contains the receptor binding domain (RBD) and directly binds to the peptidase domain of ACE2 on the surface of cells. This spiking results in endocytosis and translocation of both virus and the enzyme, where S2 is responsible for the membrane fusion<ref>PMID:18227861</ref>. | ||
SARS-CoV RBD and SARS-CoV-2 RBD shares similarity<ref>DOI: 10.1126/science.abb2762</ref>; but various conformational deviations are found. Substitution from SARS-CoV_RBD to SARS-CoV-2-RBD of Val404→Lys417, Tyr442→Leu455, Leu443→Phe456, Phe460→Tyr473, and Asn479→Gln493 may change affinity for ACE2. | SARS-CoV RBD and SARS-CoV-2 RBD shares similarity<ref>DOI: 10.1126/science.abb2762</ref>; but various conformational deviations are found. Substitution from SARS-CoV_RBD to SARS-CoV-2-RBD of Val404→Lys417, Tyr442→Leu455, Leu443→Phe456, Phe460→Tyr473, and Asn479→Gln493 may change affinity for ACE2. | ||
== References == | == References == | ||
<references/> | <references/> | ||
