Sandbox Reserved 1601: Difference between revisions
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Regulation of the uptake and efflux of calcium is important to increase calcium levels enough to activate certain enzymes, but also avoid calcium overload and apoptosis.<ref name="Wang"/> Mitochondrial calcium increases ATP production by activating pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and isocitrate dehydrogenase in the Krebs cycle.<ref name="Wang"/> Therefore, deficiency of MCU leads to decrease of enzyme activity and of oxidative phosphorylation. | Regulation of the uptake and efflux of calcium is important to increase calcium levels enough to activate certain enzymes, but also avoid calcium overload and apoptosis.<ref name="Wang"/> Mitochondrial calcium increases ATP production by activating pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and isocitrate dehydrogenase in the Krebs cycle.<ref name="Wang"/> Therefore, deficiency of MCU leads to decrease of enzyme activity and of oxidative phosphorylation. | ||
==Structure== | ==Structure== | ||
===Mitochondrial Calcium Uniporter Complex=== | ===Mitochondrial Calcium Uniporter Complex=== | ||
The actual mitochondrial calcium uniporter exists as a large complex (around 480 kDa in humans) made up of both pore-forming and regulatory subunits.<ref name="Wang"/> | |||
===Mitochondrial Calcium Uniporter Structure=== | ===Mitochondrial Calcium Uniporter Structure=== | ||
