Sandbox Reserved 1601: Difference between revisions
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===Neurodegenerative Disorders=== | ===Neurodegenerative Disorders=== | ||
Disruption in calcium homeostasis leads to a wide range of neurodegenerative disorders. The MCU complex has been identified to play a large role in neuromuscular disease because of a loss or mutation of MICU1.<ref name="Woods"/> This causes myopathy, learning difficulties, and progressive movement disorders which can be lethal.<ref name="Woods"/> In Alzheimer's disease, the buildup of amyloid-β plaques in the brain leads to increased calcium uptake in neurons and cell death.<ref name="Woods"/> Similarly, in early onset Parkinson's Disorder, degradation of MICU1 by the protein ligase Parkin | Disruption in calcium homeostasis leads to a wide range of neurodegenerative disorders. The MCU complex has been identified to play a large role in neuromuscular disease because of a loss or mutation of MICU1.<ref name="Woods"/> This causes myopathy, learning difficulties, and progressive movement disorders which can be lethal.<ref name="Woods"/> In Alzheimer's disease, the buildup of amyloid-β plaques in the brain leads to increased calcium uptake in neurons and cell death.<ref name="Woods"/> Similarly, in early onset Parkinson's Disorder, degradation of MICU1 by the protein ligase Parkin leads to increased mitochondrial calcium uptake, overload, and death.<ref name="Woods"/> Finally, disrupted glutamate homeostasis in astrocytes and neurons leads to calcium overload and cell death via excitotoxicity in Amyotrophic Lateral Sclerosis (ALS).<ref name="Woods"/> | ||
===Diabetes=== | ===Diabetes=== | ||
