Sandbox Reserved 1606: Difference between revisions
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===Inhibitors=== | ===Inhibitors=== | ||
[[Image:ko143 and mz29 abcg2 inhibitors.png|250 px|right|thumb|Figure 3. (Top) Known ABCG2 | [[Image:ko143 and mz29 abcg2 inhibitors.png|250 px|right|thumb|Figure 3. (Top) Known ABCG2 Inhibitor Kol143; Red numbers indicate points of alternation in derivates of inhibitors. (Bottom) Derivative of Kol143, MZ26.]] | ||
Due to the potential for ABCG2 inhibition to aid in cancer treatment, efforts have been made to develop specific inhibitors of ABCG2 and other ABC transporters. The ABC transporter ABCB1, also known as multidrug resistance 1 (MDR1), was a therapeutic target in previous studies which produced three generations of MDR1 inhibitors, such as [https://en.wikipedia.org/wiki/Verapamil verapamil], [https://en.wikipedia.org/wiki/Valspodar valspodar], and [https://en.wikipedia.org/wiki/Zosuquidar zosuquidar]; however, many of these inhibitors had neurotoxic effects that discouraged their use as anticancer drugs.<ref name="Leonard"/><ref name="Binkhathlan"/><ref name="Witherspoon"/> | Due to the potential for ABCG2 inhibition to aid in cancer treatment, efforts have been made to develop specific inhibitors of ABCG2 and other ABC transporters. The ABC transporter ABCB1, also known as multidrug resistance 1 (MDR1), was a therapeutic target in previous studies which produced three generations of MDR1 inhibitors, such as [https://en.wikipedia.org/wiki/Verapamil verapamil], [https://en.wikipedia.org/wiki/Valspodar valspodar], and [https://en.wikipedia.org/wiki/Zosuquidar zosuquidar]; however, many of these inhibitors had neurotoxic effects that discouraged their use as anticancer drugs.<ref name="Leonard"/><ref name="Binkhathlan"/><ref name="Witherspoon"/> | ||
