Sandbox Reserved 1627: Difference between revisions
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==Structural Overview== | ==Structural Overview== | ||
The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/3'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures of the entirety of the receptor based on the function of downstream tyrosine autophosphorylation.[https//www.rcsb.org/structure/1ir3 PDB 1IR3] | The insulin receptor is a [http://en.wikipedia.org/wiki/Dimer_(chemistry) dimer] of heterodimers made of two <scene name='83/832953/Alpha_subunits/4'>alpha subunits</scene> and two <scene name='83/832953/Beta_subunits/3'>beta subunits</scene> <ref name="Tatulian">PMID:26322622</ref>. Within the extracellular ectodomain, there are four potential <scene name='83/832953/Binding_sites/3'>binding sites</scene> that can interact with insulin ligands on the extracellular side of the membrane. The insulin receptor has only been imaged in pieces, which has led to proposed structures of the entirety of the receptor based on the function of downstream tyrosine autophosphorylation.[[https//www.rcsb.org/structure/1ir3 PDB 1IR3]] | ||
====Alpha Subunits==== | ====Alpha Subunits==== | ||
